Cambridge Major Laboratories, Inc. Jobs in Wisconsin

Company:
Cambridge Major Laboratories, Inc.
Current Opportunities (0)
Location(s):
W130 N10497 Washington Drive
Germantown,  WI
53022
Map Location
Phone:
(262) 251-5044
Industry:
Healthcare / Pharmaceuticals / Medical
Size:
Not available

Company Overview

BUSINESS MODEL

At Cambridge Major we pride ourselves not only in our operational flexibility, but our flexibility in creating collaborations tailored to your specific needs. We understand that time is a critical parameter in your development program, and the last thing you want is to lose precious time waiting on proposals or going round and round in contract negotiations. At Cambridge Major you'll get a complete technical proposal within a week (many within 2-3 days). And we'll create a full range of business approaches to fit your requirements. Our business process from Confidentiality Agreement through to Project Completion is uncomplicated and streamlined.

FACILITY

In 2004 CML opened a new, state-of-the-art GMP facility encompassing over 50,000 square feet of space. The facility enables the company to provide advanced chemistry services from early pre-clinical to post-NDA commercial manufacture of API’s. The design included many features that will enable CML to continue its tradition of fast and flexible operation with an eye on safety and material flow. The facility includes:

  • 4 Process R&D Labs
  • 5 GMP Kilo Lab Suites
  • 2 Mini-Plant Suites (to 100gal)
  • 2 Main Plant Bays (to 500gal)
  • 2 Hydrogenation Suites
  • 3 Isolated Drying Suites
  • 1 Packaging Suite
  • Analytical Laboratories
  • Solvent and Bulk Material Storage Building
CHEMISTRY

At Cambridge Major Laboratories, we provide a vast array of chemical services that range from the development of routes where no synthetic procedures exist, to production using protocols supplied by our customers. With over 25 years of manufacturing experience, we can accommodate custom synthesis projects that range from simple small molecules to the most challenging and complex compounds. Our philosophy to do whatever it takes to get the job done, coupled with an obsessive focus on delivery, makes us the right choice for all your chemistry needs.

Our equipment allows us to handle projects from gram to tonnage scale, as well as temperature ranges from -80°C to 250°C and pressures up to 300 psi. We routinely carry out organolithium and Grignard reactions, and handle azides, phosgene and other difficult reagents.

Our expertise lies in palladium and nickel catalyzed coupling reactions, including Suzuki, Stille, Heck, Sonogashira, and Negishi; as well as heterocyclic reactions, biphenyls and fluorenes, nucleosides, carbohydrates, and phosphitylating reagents.

Cambridge Major’s scientists have also developed an extensive collection of compounds that can be used for combinatorial libraries and screening, or to support customer developmental supplies.

We have entered into a development and marketing alliance with BP to provide our customers with a wide range of novel Oxazole Derivatives based on proprietary technology. These compounds can be used as basic building blocks for the newest classes of biologically active compounds, and have been previously unavailable due to the extreme difficulty of synthesizing the Oxazole ring. The Oxazole structure itself has proven to be an interesting substitution for any existing heterocycle fragment, and can be a cost-effective solution for the synthesis of an existing drug candidate. In addition, Oxazole can serve as a bioisotere of an amide functional group and may be its suitable replacement, and thus provide novel analogs with similar biological activities.

Cambridge Major is also one of the world largest suppliers of high quality reagents into the biopharmaceutical Oligonucleotide Market. One of our most broadly applied production technologies is used in ultra high purity phosphitylating reagent, ("Phos Reagent") used to activate nucleosides. From there the activated compound is added to the DNA synthesizer in the appropriate sequence to form the desired oligo. Our high purity phos reagent makes downstream purification of oligos much simpler, leading to lower overall cost of production and much higher quality. In addition to Phos Reagent, we also have technology to produce Menpoc Chloride, a photolabile 5' protecting group, as well as high purity Hexaethylene Glycol (HEG), a linker for oligos.